The First Prophecy - Embryonic Gospel

The first prophecy in the Bible is spoken to the serpent. God promised the serpent that the Seed of the woman will bruise his head.

And I will put enmity
Between you and the woman,
And between your seed and her seed;
He shall bruise you on the head,
And you shall bruise him on the heel.
(Genesis 3:15 NASB)

Who is this Seed of the woman? It become clearer in another prophecy in Isaiah.

Therefore the Lord himself shall give you a sign; Behold, a virgin shall conceive, and bear a son, and shall call his name Immanuel. (Isaiah 7:14 KJV)

And it was fulfilled.

But while he thought on these things, behold, the angel of the Lord appeared unto him in a dream, saying, Joseph, thou son of David, fear not to take unto thee Mary thy wife: for that which is conceived in her is of the Holy Ghost. And she shall bring forth a son, and thou shalt call his name Jesus: for he shall save his people from their sins. Now all this was done, that it might be fulfilled which was spoken of the Lord by the prophet, saying, Behold, a virgin shall be with child, and shall bring forth a son, and they shall call his name Emmanuel, which being interpreted is, God with us. Then Joseph being raised from sleep did as the angel of the Lord had bidden him, and took unto him his wife: And knew her not till she had brought forth her firstborn son: and he called his name Jesus. (Matthew 1:20-25 KJV)

Now it is clear why it is the Seed of the woman, and not of the man. He was chosen before the foundation of the world but was revealed at the end of the times for us, redeeming us with His precious blood. That is why the very first prophecy in the Bible is about Jesus Christ, the Seed of the woman, but not of the man.

He was chosen before the foundation of the world but was revealed at the end of the times for you who through Him are believers in God, who raised Him from the dead and gave Him glory, so that your faith and hope are in God. (1 Peter 1:20-21 HCSB)